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Testosterone is a vital steroid hormone produced primarily in the testes in males and in smaller amounts in the ovaries in females. It plays a crucial role in the development and maintenance of male reproductive tissues, bone mass, and overall health.

Testosterone is responsible for:

1. Masculinization: Development of male characteristics, such as facial hair, deep voice, and muscle mass.
2. Reproductive health: Regulation of sperm production, fertility, and libido.
3. Bone health: Maintenance of bone density, reducing the risk of osteoporosis.
4. Muscle mass and strength: Regulation of muscle growth and maintenance.
5. Red blood cell production: Stimulation of erythropoiesis, which produces red blood cells.
6. Cognitive function: Influence on cognitive abilities, such as memory and concentration.
7. Mood regulation: Contribution to mood stability and reduced risk of depression.

Imbalances in testosterone levels can lead to various health issues, such as hypogonadism (low testosterone).

Testosterone optimization therapy (TOT) is a medical treatment that aims to restore testosterone levels to a healthy range. The benefits of TOT can vary depending on the individual, but here are some potential advantages:

1. Improved libido and sex drive: Testosterone plays a crucial role in regulating sex drive and erectile function. TOT can help restore a healthy sex life.
2. Increased energy and vitality: Low testosterone levels can lead to fatigue, lethargy, and decreased motivation. TOT can help boost energy levels and overall sense of well-being.
3. Weight loss and improved body composition: Testosterone helps regulate metabolism and fat distribution. TOT can aid in weight loss and improve muscle mass and strength.
4. Enhanced cognitive function: Testosterone has been linked to improved cognitive function, including better memory, concentration, and mood.
5. Improved bone density: Testosterone helps maintain bone density, reducing the risk of osteoporosis and fractures.
6. Reduced risk of chronic diseases: Low testosterone levels have been linked to an increased risk of chronic diseases, such as heart disease, diabetes, and certain types of cancer. TOT may help mitigate these risks.
7. Improved mental health: Testosterone has been shown to have a positive impact on mental health, reducing symptoms of depression and anxiety.
8. Improved sleep quality: TOT can help regulate sleep patterns and improve overall sleep quality.
9. Increased muscle mass and strength: Testosterone is essential for muscle growth and maintenance. TOT can help improve muscle mass and strength.
10. Improved overall quality of life: By addressing low testosterone levels, TOT can have a positive impact on overall quality of life, enabling individuals to feel more energetic, confident, and motivated.

It’s essential to note that TOT should only be undertaken under the guidance of a qualified healthcare professional. They will help determine if TOT is suitable for you and monitor your progress to ensure safe and effective treatment.

Sources:

– American Urological Association (AUA)

– Endocrine Society

– Journal of Clinical Endocrinology and Metabolism

– Mayo Clinic

The aim of testosterone optimisation therapy to get your free testosterone levels up to a physiological high normal. That means that we are trying to elevate your free testosterone to a level of 600-750pmol/L. The reason why we aim for the physiological high level, and avoid making your free testosterone levels super-physiological, is to basically mimic what your body is not producing. This ensures that there is no side effect profile, as we are respecting the body’s physiology.

This is done with an option of two treatments:

• Micro-dosing Principle

This entails injecting yourself with small amounts of testosterone cypionate twice a week, normally on a Monday and Thursday. Please see the attached link on how the testosterone is self administered: 

2. Bio-Identical Testosterone Cream

This cream is applied on a daily basis to the skin of the abdomen with a dose metered pump, and is absorbed through the skin into the systemic physiology. One pump of the cream will be your equivalent daily dose. It is rubbed onto the skin of the abdomen. It is advised that this is done after exposure to water, such as a bath or shower, and you should wash your hands after handling the cream to avoid transfer to other people.

We do advise using the injectable treatment as this is the ‘gold standard’ and may be more effective than the cream, but we do understand that some patients are afraid of needles and may prefer using the cream.

In order to ascertain if we have elevated your free testosterone levels to a physiological high, we do follow up blood tests 8 to 12 weeks after you commence the therapy, mainly checking only your testosterone and oestrogen levels, and any other biomarkers that were of concern based on your initial blood-work. 

If your free testosterone levels are within the optimal physiological level, your therapy will continue as initially prescribed. If your levels still need improvement, the concentration of your testosterone vial or cream will be adjusted accordingly with your next delivery. If it is too high, it will be decreased accordingly with your next delivery. This will be communicated with you via email.

If your follow up bloods show minimal increase with the cream, our medical team may advise switching over to the injectable treatment.

Even once we know that we have elevated your free testosterone levels into an optimal level, we still do follow up bloods every 5-6 months, in order to continually monitor your levels and physiology.

This ensures a total medically guided testosterone optimisation programme that gives you peace of mind that your physiology and your health are being monitored on a continuous basis.